Arising from remnants of tooth development

Benign tumors

A) Odontogenic epithelium, without odontogenic ectomesenchyme

1. Ameloblastoma
2. Calcifying epithelial odontogenic tumor (Pindborg tumor) (CEOT)
3. Squamous odontogenic tumor (SOT)
4. Adenomatoid odontogenic tumor (AOT)
5. Keratocystic odontogenic tumor (KCOT)

B) Odontogenic epithelium + odontogenic ectomesenchyme ± dental hard tissue formation

1. Ameloblastic fibroma
2. Ameloblastic fibrodentinoma & ameloblastic fibro-odontoma
3. Odontoameloblastoma
4. Calcifying cystic odontogenic tumor (Gorlin cyst)
5. Odontoma

C) Odontogenic ectomesenchyme ± odontogenic epithelium

1. Odontogenic fibroma
2. Myxoma (odontogenic myxoma, myxofibroma)
3. Cementoblastoma

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Malignant tumor

A) Odontogenic carcinoma (epithelial origin)

1. Ameloblastic carcinoma
2. Primary intraosseous squamous cell carcinoma
3. Clear cell odontogenic carcinoma
4. Ghost cell odontogenic carcinoma

B) Odontogenic sarcoma (mesenchymal origin)

1. Ameloblastic fibrosarcoma
2. Ameloblastic fibro-dentinosarcoma
3. Ameloblastic fibro-odontosarcoma

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Bone related lesions

1. Ossifying fibroma (cemento ossifying fibroma)
2. Fibrous dysplasia of bone
3. Osseous dysplasia (cemento osseous dysplasia)
   • Focal COD
   • Periapical COD
   • Florid COD
4. Central giant cell lesion
5. Cherubism
6. Aneurysmal bone cyst
7. Simple bone cyst (solitary, traumatic, hemorrhagic)