Melanotic neuroectodermal tumor of infancy (MNTI)

  • Rare osteoclastic and pigmented neoplasm, primarily affects jaws of infants
  • Rapidly growing neoplasm
  • Presents in first 4 months after birth
  • M : F = 6 : 7


  • Maxilla (common)
  • Mandible
  • Rare: Skull, long bones, epididymis, mediastinum

Clinical: Expanding blue-black lesion – causes facial asymmetry – displacement of lip and alter base of nose + destruction of alveolar bone


  • Arise from neural crest cells associated with tooth germ
  • Malignancy rare
  • Can recur

Radiology: Multiple areas of radiolucency – associated with displacing teeth

Histology: Neuroblasts + pigment containing cells forming ducts and tubules


  • FNA
  • VMA (Vanillylmandelic acid) – monitor recurrence

Differential diagnosis:

Management: Surgical excision (15-20% recurrence)


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