Liposarcoma

Origin: Adipocytes, rare in head and neck

Clinical: Slow growing mass

Subtypes:

• Well differentiated
• Myxoid
• Round cell
• Pleomorphic

Management:

• Surgical excision with radiation
• Good prognosis

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Leiomyosarcoma

Origin: Spindle shaped smooth muscle cells

Resembles fibrosarcoma clinicopathologically, therefore to differentiate in diagnosis

Diagnosis: +ve desmin and +ve actin

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Rhabdomyosarcoma

Origin: Striated muscle

Diagnosis: +ve desmin and +ve actin

Management: Surgery, chemotherapy, radiotherapy

Histology:

2 Histological forms:

1. Embryonal:

• In head and neck and GUT
• 4-6 year olds
• Primitive round cells:
  • Spindle
  • Grape like – botryoid

2. Alveolar:

• Extremities/trunk
• > 10 year olds

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Neurofibrosarcoma

Origin: Schwann cells, neural cells

Clinical: Mass causing pain and paresthesia

Histology: Plump spindle cell – arranged in streaming pattern

Diagnosis: If resembles fibrosarcoma, confirm with S-100 staining

Management: Surgery and radiation

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