• ↓ Thyroid hormone

Etiology:

• Congenital defects of the thyroid
• Iodine deficient goiter
• Autoimmune (Hashimoto’s) thyroiditis
• Diseases of the pituitary (↓TSH)
• Hypothalamus (↓ thyrotropin releasing hormone TRH)
• Radiation injuries
• Surgical ablation
• Drugs (lithium, iodides)
• Idiopathic causes
  

Clinical:

• Delayed mental, skeletal, dental and sexual development
• Blood: microcytic, hypochromic anemia – fatigue and lethargy
• Dermal: dry and scaly skin, facial oedema.
  

Management: Gradual replacement therapy + synthetic and natural thyroid hormone preparations.

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