1. Sexually transmitted (acquired)

Primary – Chancre (chronic ulcer) Picture

Secondary

• Oral mucosal patches
• Condyloma latum
• Maculopapular rash
• Organopathy

Tertiary

• Gumma (non cancerous growth) Picture
• Destructive ulcers
• CNS disease – Neurosyphilis:
  • Meningovascular lesions
  • Tabes dorsalis
  • General paresis
• CVS disease – Aortitis:
  • Aneurysms
  • Aortic regurgitation and gumma

NB: Can go into latency

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2. Vertically transmitted (congenital)

Early

• Spirochetosis
• Dental defects
• Deafness
• Ocular Keratitis
• Bone and joint lesion
• Organopathy

Late: Latency

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Diagnosis

• VDRL (Venereal Disease Research Laboratory)
• RPR (Rapid Plasma Reagin)
• ELISA

Management

• Penicillin
• Tetracycline

Notes under white lesions

Prenatal infection:

• Hutchinson’s incisors – tapered crown + notched incisal edge
• Mulberry molars – Lobulated occlusal surfaces

Picture