• Non inflammatory, non neoplastic swelling of salivary glands
• Usually bilateral and painless, affecting the parotids

Etiology: Dysregulation of the autonomic innervation of the salivary glands.

1. Drugs: Alcohol, Sympathomimetics (isoprenaline)
2. Endocrine: Acromegaly, Diabetes mellitus, Pregnancy
3. Metabolic: Liver cirrhosis, Anorexia nervosa/bulimia, Cystic fibrosis, Malnutrition
4. HIV

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