• ↓ Ascorbic acid (vit C)

Physiology: Vit C is required for redox reactions:

  • Hydroxylation of praline in collagen formation
  • Hydroxylation of dopamine to noradrenaline

Clinical: Scurvy

  • Haemorrhagic diatheses
  • Skin rash
  • Delayed wound healing
  • Anaemia
  • Scorbutic rosary – mineralization of costochondral cartilages due to deranged formation
    of osteoid
  • Generalized gingival enlargement

Histology: Hemorrhagic gingival enlargement with minimal fibrosis

Management: Replacement therapy


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