• ↓ Ascorbic acid (vit C)

Physiology: Vit C is required for redox reactions:

• Hydroxylation of praline in collagen formation
• Hydroxylation of dopamine to noradrenaline

Clinical: Scurvy

• Haemorrhagic diatheses
• Skin rash
• Delayed wound healing
• Anaemia
• Scorbutic rosary – mineralization of costochondral cartilages due to deranged formation
  of osteoid
• Generalized gingival enlargement

Histology: Hemorrhagic gingival enlargement with minimal fibrosis

Management: Replacement therapy

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