Solitary/multiple subtypes

Etiology:

• Developmental disorder of nerve sheaths
• Multiple neurofibromas – genetic conditions – AD trait

Clinical:

• Multiple hamartomatous tumor like masses
• Café au lait spots
• Sessile/pedunculated tumors of skin
• Neural tumors

• Malignant change: 5-15% of cases to neurofibrosarcoma
• No treatment, surgery may cause further damage
• Check ups only

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