A focal area of granulomatous inflammation – consisting of multinucleate macrophages
- Epithelioid appearance of macrophages, surrounded by mononuclear leukocytes (mainly lymphocytes and plasma cells)
- As lesion matures – develops a rim of fibrous CT
Infectious granulomas – also called immune granulomas because:
- Macrophages ingest resistant bacteria (eg. Mycobacteria) → activate T cells → produce IFN gamma → causes transformation of macrophages into giant cells
- Giant cells – also observed in foreign body reactions eg. sutures and amalgam
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