• Increased GH, ACTH and TSH
• Rare metabolic condition characterized by bony and soft tissue overgrowth and metabolic hypersecretion

Etiology: Benign pituitary adenoma – chronic hypersecretion of GH, ATCH and TSH

NB: If hypersecretion occurs prior to closure of epiphyseal growth plates, gigantism will occur

Clinical:

A) Systemic:

1. Hyperhidrosis (increased sweating)
2. Hirsutism (masculinization)
3. Impotence
4. Muscle weakness
5. Paresthesia
6. Carpal tunnel syndrome
7. Sleep apnoea
8. Hypertension
9. Heart disease

B) Bone:

1. New periosteal bone formation
2. Cartilaginous hyperplasia
3. Frontal bossing
4. Nasal bone hypertrophy

C) Oral:

1. Mandibular prognathism (increase in mandibular condyle)
2. Acquired malocclusion
3. Macroglossia

Lab: In serum, increased GH, ACTH, TSH and testosterone

Management:

• Transsphenoidal surgery
• Radiotherapy
• Bromocriptine (dopamine activator)

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